Purity 98%. ABT-639 is a potent and selective T-type calcium channel blocker. ABT-639 effectively reduces nociceptive and neuropathic pain in rats. ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. ABT-639 was significantly less active at other Ca2 channels (e.g. Ca (v)1.2 and Ca (v)2.2) (IC > 30 muM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and