Purity 95% (SDS-PAGE). CCL22 (monocyte-derived chemokine) was described initially as a constitutively produced, thymus-specific chemokine, implicated in the recruitment of T cells. One of the functions of CCL22 originally described was induction of migration of CCR4+ Th2 cells, but it has additionally been shown to regulate migration of Tregs. CCL22 has been implicated in a number of diseases, including allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Similarly, a presumed role for CCR4+ cells has been suggested for endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. Source: Recombinant protein corresponding to human CCL22 expressed in E. coli. Molecular Weight: ~8kD Biological Activity: The ED50 was determined by the dose-dependent proliferation of MGC823 cells and was <5ng/mL. Endotoxin: <1EU/ug (LAL)
Size
20ug
Concentration
n/a
Applications
n/a
Other Names
CCL22, Recombinant, Human (STCP-1, ABCD-1, CC Chemokine STCP-1, MDC(1-69), SCYA22, Small-Inducible Cytokine A22, Stimulated T-Cell Chemotactic Protein 1, MDC, C-C Motif Chemokine 22, Macrophage-Derived Chemokine)