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Description
Produces an IgG1 monoclonal antibody (Catalog #522) which reacts with HIV-1LAV/HTLV-IIIB gp120 in immunoprecipitation and Western blot assays. Neutralizes infectivity and reacts with cells expressing the envelope proteins of these strains. Binds to the immunodominant hypervariable loop of gp120 (unpublished results). Does not recognize other HIV-1 strains. Mice were immunized via tail scratch with a vaccinia virus expressing gp160. Three-five weeks later, mice received two intraperitoneal inoculations with the same virus. Three days after the second inoculation, mouse spleen cells were fused with NS-1 cells.