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Description
Rabbit IgG polyclonal Picoband? antibody for DARS2 detection. Tested with WB, IHC-P, Direct ELISA in Human. No cross reactivity with other proteins. DARS2 contains conserved residues involved in ATP binding, tRNA binding, and aspartic acid recognition, as well as catalytic site motifs characteristic of amino acid tRNA synthetases. The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). The International Radiation Hybrid Mapping Consortium mapped the DARS2 gene to chromosome 1.
Immunogen
E.coli-derived human DARS2 recombinant protein (Position: D334-A448).