An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 μM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 μM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion ,