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Description
Marker for vascular cell adhesion molecule VCAM-1. Monoclonal antibody 1299-27-1 recognizes VCAM-1 (vascular cell adhesion molecule 1) expressed by endothelial cells in tissue sections and in umbilical vein endothelial cells (HUVECs) stimulated by TNF-? or Interleukin (IL)-1. VCAM-1 is known to be a receptor for the integrin ?4?1, and to interact weakly with the closely related integrin ?4?7. The primary leucocytes that interact with CD106 are lymphocytes, monocytes, basophils and eosinophils. Neutrophils lack the ?4 integrin, which explains some of the selective adhesion and recruitment characteristics of the different leucocytes. VCAM-1 is expressed in a wide range of inflammatory conditions, including rejecting cardiac transplant tissue, atherosclerotic lesions, multiple sclerosis, arthritic synovium and inflammatory reactions in the skin. Application: IHC (f)