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Description
MEM-48 recognizes the human ?2 integrin subunit that pairs each of four distinctive CD11 ? subunits to form the CD11/CD18 integrin heterodimers. MEM-48 potently promoted adhesion of LFA-1/K562 transfectants and neutrophils to their respective immobilized ligands, suggesting it to be one of the select class of monoclonal antibodies which can act on the ectodomain of the integrin to induce adhesion. Expression of the epitope recognized by MEM-48 is minimal on ?2 integrin transfectants, T cells, eosinophils, monocytes and neutrophils. Application: IHC (f), FACS, Immunoprecipitation, Western Blot (non-reduced)