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Description
Early B-cell marker absent from plasma cells. Monoclonal antibody 32D12 recognizes the CD24 antigen which is expressed throughout B-cell development and is downregulated as bone marrow progenitors mature. CD24 expression is lost when human B-cells become plasma cells. The cellular function for human CD24 is unknown so far. Diagnostically, it can serve as a marker for staging B-cell development, and it is expressed at high levels in small cell lung carcinoma. CD24 is a member of a family that also includes heat stable antigen (HSA) and CD52. It is a glycosylphosphatidylinositol (GPI) anchored glycoprotein.