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Description
Marker for the transferrin receptor. Monoclonal antibody SOM4D10 recognizes the human CD71 antigen, the transferrin receptor. CD71 is a proliferation-associated homodimeric membrane glycoprotein consisting of two disulfide-bonded 95kD chains. CD71 is a type II membrane protein with short aminoterminal cytoplasmic domain, which mediates internalization and recycling, a single transmembrane region, and a large extracellular transferrin-binding domain. CD71 contains N-linked and O-linked glycans, as well as palmitic acid covalently attached to cysteine residues close to the cytoplasmic face of the membrane. Application: IHC (f), FACS