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Description
Monoclonal antibody OX-90 reacts with CD200 (OX-2 antigen), a type-1 membrane glycoprotein containing two extracellular Ig-like domains. The molecular weight of the OX-2 antigen is 41 to 47kDa. CD200 is expressed on thymocytes, neurons, B lymphocytes, splenic follicular dendritic cells and endothelium, and subsets of T lymphocytes and dendritic cells: The antigen is not expressed on NK cells, granulocytes, monocytes or macrophages. The CD200 receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in the activation of anti-inflammatory pathways and the induction of immune tolerance. Application: IHC (f,p), FACS, ELISA