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Description
UniProt: Q6L5J4. FPRL2 is a 353 amino acid G protein-coupled receptor. Its particular distribution on macrophage subsets of the lung, intestine and skin suggest an involvement in innate immunity against helminths or in allergic diseases. Fittingly, the receptor has also been identified on eosinophils, but not on neutrophils. The endogenous peptide F2L, an acetylated 21 amino acid peptide derived from heme-binding protein, is a most specific ligand for FPRL2 and causes chemotaxis but not degranulation in human eosinophils., F2L is also chemotactic for plasmacytoid dendritic cells which express FPRL2 and up-regulate this receptor during maturation. Application: IHC (f)