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Description
Marker for MHC class II. Monoclonal antibody FN81 recognizes the HLA-DQ antigen, an HLA class II antigen with homology to murine H-2A. HLA class II antigens are mainly expressed on specialized antigen presenting cells (APCs): dendritic cells, B-cells, and macrophages. HLA class II antigen is presented on activated T-cells. HLA class II molecules present exogenously derived antigen to the T-cell receptor (TCR) on CD4? T lymphocytes. Both chains in HLA-DQ are polymorphic. HLA-DQ is expressed after DR and DP during haematopoietic progenitor cell development. It is strongly expressed in the thymic cortex. Application: IHC (f), FACS