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Description
Marker for human leukocyte antigen class II. Monoclonal antibody HKB1 recognizes all HLA class II antigens, the 3 major (HLA-DP, -DQ and -DR) and 2 minor major histocompatibility complex MHC class II proteins (HLA-DM and -DO). The genes of the class II combine to form heterodimeric (? ?) protein receptors that are typically expressed on the surface of antigen presenting cells (APCs): dendritic cells, B-cells, and macrophages. HLA class II is presented on activated T-cells. HLA class II molecules present exogenously derived antigen to the T-cell receptor (TCR) on CD4? T lymphocytes. Application: IHC (f), FACS