Zinc and Ring Finger Protein 1 (ZNRF1) (AA 74-178) protein (His tag)
Description
E3 ubiquitin-protein ligase ZNRF1 contains one ring-type zinc finger, high expressed in the nervous system and developing brain, low expressed in testis and thymus. ZNRF1 mediates the ubiquitination of AKT1 and GLUL, so it plays a role in neuron cells differentiation. It also has a role in the establishment and maintenance of neuronal transmission and plasticity. ZNRF1 regulates Schwann cells differentiation by mediating ubiquitination of GLUL.Alternative Names: E3 ubiquitin-protein ligase ZNRF1, nerve injury-induced gene 283 protein, zinc/ring finger protein 1, NIN283, ZNRF1