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Description
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family.This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli.It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3.This kinase is phosphorylated, and thus activated by MAP3K1/MEKK.The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle.It is also widely expressed in other tissues.
Immunogen
Purified recombinant fragment of human MAP2K4 expressed in E. coli.