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Description
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Acts as a co-receptor for HCV entry into hepatic cells.Subcellular location: Cell junction ?? tight junction. Cell membrane, Multi-pass membrane proteinTissue specificity: Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Also known as: Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1.
Immunogen
A synthetic peptide from 3d cytoplasmic domain of mouse Claudin 1 (SEMP1) conjugated to an immunogenic carrier protein was used as the antigen.