Glycogen Synthase Kinase 3 beta, active, Recombinant, Human (GSK3b)
Description
Purity ≥ 90% by densitometry. GSK-3β is a Serine/Threonine protein kinase that was originally identified as the kinase that phosphorylates and inhibits glycogen synthase (1). GSK-3β is ubiquitously present in human tissues and implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin and modulation of the transcription factors AP-1 and CREB. Transient transfection of human GSK-3β into Chinese hamster ovary cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies (2). Source: Recombinant full-length human GSK-3β was expressed by baculovirus in Sf 9 insect cells using an N-terminal GST tag. The gene accession number is NM_002093. Molecular Mass: The approximate molecular weight is 73kD Activity: The specific activity of GSK-3β was determined to be 101 nmol/min/mg using a