Purity ~80% (SDS-PAGE). CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. Source: Recombinant protein corresponding to aa25-372 from human CD5, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~41kD (371aa) Applications: Suitable for use in SDS-PAGE.