Purity ~90% (SDS-PAGE). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacent of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dentia), although the molecular basis for this phenomenon has not been described to date. Source: Recombinant protein corresponding to aa6-294 from human AATF, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~58.8kD AA
Size
10ug, 50ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
Apoptosis-antagonizing transcription factor Rb-binding protein Che-1