Purity ~85% (SDS-PAGE). ZWILCH belongs to the ZWILCH family. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Source: Recombinant protein corresponding to aa1-591 from human ZWILCH, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~69.6kD (614aa) Applications: Suitable for use in SDS-PAGE.