Recombinant Human Twinkle protein, mitochondrial (PEO1)
Description
Purity > 90% as determined by SDS-PAGE. MW: 75.5kDa. Full Length of Mature Protein: 32-684aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as tplate to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Progressive external ophthalmoplegia 1 protein; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase