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| Antigenic Specificity | SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (aa 538-626) |
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| Clone | S367-51 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | alkaline phosphatase (AP) conjugate |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunofluorescence (IF),Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.Cellular Localization: Cytoplasm, Cell Junction |
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| Immunogen | Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2. |
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| Other Names | DEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2|Prosap2|AI841104|Shank3b |
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| Gene, Accession # | Gene ID: 58234,59312 |
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| Catalog # | ABIN1741260 |
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| Price | |
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| Order / More Info | SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (aa 538-626) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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