Lck (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers. Colon cancers and T-cell leukemias frequently show defective regulation of Lck expression and activity.Inappropriate T cell activation and proliferation have been identified as an early event in auto-immu
Size
5 μg
Concentration
5μg/50 μl
Applications
RUO
Other Names
Lck (or leukocyte-specific protein tyrosine kinase), Leukocyte C-terminal Src kinase, Short name=LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK