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Description
Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 6(CXCR6) detection. Tested with WB, IHC-P in Human. No cross reactivity with other proteins. CXCR6(Chemokine,CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al.(1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al.(2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al.(2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo(322-342aa EDNSKTFSASHNVEATSMFQL), different from the related mouse and rat sequences by three amino acids.