An orally available, selective 5-LO inhibitor; inhibits acute and allergic bronchoconstriction, glycoconjugate secretion, and late-phase eosinophil accumulation induced by allergen inhalation in guinea pigs; reduces LPS-induced expression of iNOS, NO production, and NF-κB activation in BV2 microglial cells; reduces neurological deficits in a rat model of ischemic stroke; inhibits iNOS expression and NO production in vivo,,