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Description
HSD11B1 Antibody is a Rabbit Polyclonal antibody against HSD11B1. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Immunogen
Recombinant protein of human HSD11B1.
Other Names
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid; HDL; HSD11B; CORTRD2; SDR26C1; hydroxysteroid (11-beta) dehydrogenase 1; short chain dehydrogenase/reductase family 26C, member 1