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Description
PE/Cy7 anti-mouse CD152. CD152, also known as?CTLA-4 or Ly-56, is a 33 kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Immunogen
Mouse CTLA-4-mouse IgG2a fusion protein
Other Names
Cytotoxic T Lymphocyte-Associated Antigen-4, CTLA-4, Ly-56