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Description
NEFH/NEFM/NEFL Monoclonal Antibody (RMdO-20). Neurofilaments are the intermediate (10-12 nm) filament proteins (IFPs) located specifically in neurons, and are composed predominantly of three classes/subunits of neurofilaments: NF-L (low molecular weight; 68 kDa), NF-M (medium molecular weight; 160 kDa), and NF-H (high molecular weight; 200 kDa), with some variation in different species. The neurofilaments are long helical proteins involved in the maintenance of neuronal caliber, which polymerize to form a rigid cytoskeleton in the neuron. Like most other IFPs, the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. This polymerized network is composed of all three filaments, and the stoichiometry
Immunogen
n/a
Other Names
NEFM; neurofilament medium polypeptide; NEF3; NF-M; NFM; neurofilament triplet M protein; neurofilament medium polypeptide 150kDa; neurofilament-3, NFH, NF-H, NHC, 200 kDa neurofilament protein, KIAA0845, Neurofilament heavy polypeptide, Neurofilament triplet H protein, NFL, NF-L, NLC, 68 kDa neurofilament protein, 70 kDa neurofilament protein, CMT1F, CMT2E, Neurofilament light polypeptide, neurofilament medium, neurofilament light, neurofilament heavy