ELISA: Assay Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: 1 μg/mL
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Description
NF-H Monoclonal Antibody (NF-05). Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H
Immunogen
n/a
Other Names
NFH, 200 kDa neurofilament protein, NF-H, neurofilament heavy polypeptide, neurofilament triplet H protein, neurofilament, heavy polypeptide 200kDa