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Description
alpha Internexin Monoclonal Antibody (2E3). Alpha-internexin (a-internexin) is a type IV intermediate filament originally discovered as it copurified with other neurofilament subunits. On SDS-PAGE gels it runs with an apparent molecular weight of 64 to 66 kDa, with some species variability, although the real molecular weight is about 55kDa; as with the other neurofilament subunits the presence of highly negatively charged sequences results in reduction of SDS-PAGE mobility. A-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M, and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal developmen