Obestatin is an amidated peptide of 23 amino-acids with an alpha-helical secondary conformation. It was first isolated from rat stomach in 2005. Obestatin is a preproghrelin-derived peptide produced by many tissues or organs, including the stomach, pancreas, adipose tissue, skeletal muscle, and heart. Obestatin was originally identified as an anorexigenic peptide that reduces food intake and body weight by opposing the actions of ghrelin. It has also been considered to be an antidiabetic peptide that positively influences glucose and lipid metabolism. It may also play a role in the regulation of blood pressure as its plasma concentration increases in hypertensive patients. Obestatin may also have a role in the regulation of anxiety and memory improvement.