Purity > 90% as determined by SDS-PAGE. MW: 51.9kDa. Cytoplasmic Domain: 67-374aa. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most Extracellular domain matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the Extracellular domain matrix.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Hyaluronate synthase 2Hyaluronic acid synthase 2; HA synthase 2