Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 37kDa. Cytoplasmic Domain: 185-386aa. N-terminal 6xHis-SUMO-tagged. Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4). Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It is a short-lived protein probably degraded by the proteasome.