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Description
Polyclonal antibody to detect endogenous levels of ASK 1 protein only when phosphorylated at S83 in human. ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas through the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-α induced apoptosis.
Immunogen
Synthesized peptide derived from human ASK 1 around the phosphorylation site of S83, (20-100aa)