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Description
NALP12 Polyclonal Antibody. NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Immunogen
n/a
Other Names
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NACHT, leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; monarch-1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide