Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Western Blot: 1:1000-1:10,000
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Description
SQSTM1 Polyclonal Antibody. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD . May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.