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Description
Rabbit polyclonal antibody to TLR2. Members of the Tolllike receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (13). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NFkB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88adaptorlike/ TIRassociated protein), TRIF (Tollreceptorassociated activator of interferon), and TRAM (Tollreceptorassociated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkB that normally maintains NFkB inactivity by sequestering it in the cytoplasm.
Immunogen
Recombinant protein of human TLR2
Other Names
TLR2, CD282, TIL4, Tolllike receptor 2, Toll/interleukin1 receptorlike protein 4