If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
MyD88 (myeloid differentiation primary response gene 88) is a universal adapter protein of 296 aa used by all TLRs (except TLR3) and by IL1-R to activate the transcription factor NF-kB. Myd88 binds IRAK1, IRAK2 and TRAF6, leading to NF-kB activation, cytokine secretion and inflammatory response. Myd88 increases IL8 transcription, and is involved in IL18 signaling pathway. A monoclonal antibody was raised against huMyd88-transfected 293T cells. This antibody specifically recognizes endogenously expressed Myd88 and does not cross-react with the mouse Myd88.