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Description
TLR9 Antibody (aa205-235) LS-C187854. Recognizes an epitope within the N-terminal (NT) region of CD289, otherwise known as Toll-like receptor 9 (TLR9), a type I transmembrane glycoprotein and member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity. Is suitable for use in immunocytochemistry on acetone fixed cells.
Immunogen
Synthetic peptide SLKYNNLTVVPRNLPSSLEYLLLSYNRIVKL corresponding to amino acids 205-235 within the N-terminal domain of human CD289. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%); Monkey (97%); Marmoset (94%); Rat (90%); Mouse, Ferret, Dog, Horse, Guinea pig (84%); Hamster, Elephant, Panda, Cat, Rabbit, Pig (81%).