bovine, chicken, human, mouse, rat, Xenopus, zebrafish
Isotype
IgG
Format
unconjugated
Size
n/a
Concentration
n/a
Applications
WB
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Rabbit Anti-Human TAK1 (phospho Thr184, Thr187) monoclonal antibody for WB. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/NhpK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Immunogen
Phosphopeptide corresponding to residues surrounding pThr184 and pThr187 of human TAK1