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Description
TLR9 Antibody (aa204-224) LS-C187710. Recognizes murine Toll-like receptor 9, also known as CD289 or TLR9. CD289 is an 1032 amino acid ~120 kD endosomal single pass type I transmembrane glycoprotein with a number of and a single domain. Recognizes an epitope within the N-terminal (NT) region of CD289, a member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity and has been shown to play a role in defense against systemic mouse cytomegalovirus infection. Is reported as suitable for use in immunocytochemistry on acetone fixed cells.
Immunogen
Synthetic peptide LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminal region of mouse CD289. Percent identity by BLAST analysis: Mouse, Hamster (100%); Rat (95%); Panda, Dog, Cat, Horse, Guinea pig (90%); Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Ferret, Elephant, Pig (86%); Sheep, Goat, Zebu, Bovine, Rabbit (81%).