Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 20-152) protein (Fc Tag)
Description
GITR (Glucocorticoid-induced TNF receptor) is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T cell receptor-mediated cell death. GITR serves as a negative regulator for NK cell activation. It mediates NF-kappaB activation via the TRAF2/NIK pathway.