A second-generation analog of (R)-roscovitine that inhibits Cdk1, 2, 5, and 9 (IC50s = 0.09, 0.072-0.041, 0.11, and 0.18 μM, respectively) with improved potency over its parent compound; also inhibits CK1δ/ε (IC50 = 0.40 μM) and GSK-3α/β (IC50 = 12 μM)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
cyclin-dependent kinases CDK cells cycles cancers (R)-roscovitine Cdk1/cyclin B Cdk2/cyclin A Cdk2/cyclin E Cdk5/p25 Cdk9/cyclin T inhibitors casein kinase1 CK1δ/ε, GSK-3α/β inhibits inhibitions apoptosis glycogen induce synthase inducer CR8 CR-8