An inhibitor of the DNA damage sensor MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM); prevents activation of ATM by blocking the nuclease activity of Mre11; induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage
Size
100 mg
Concentration
n/a
Applications
n/a
Other Names
DNA damage ATM histone nuclease MRN Mre11 Rad50 Nbs1 repair