A PAR1 antagonist (Ki = 8.1 nM); selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors; inhibits thrombin- and haTRAP-induced platelet aggregation (IC50s = 47 and 25 nM, respectively); completely inhibits platelet aggregation in cynomolgus monkeys ex vivo when used at a dose of 0.1 mg/kg i.v.
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
SCH530348 Sch-530348 MK5348 MK-5348 zontivity ha-TRAP PAR-1 G protein-coupled