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Description
IL-3 exerts its biologic activity (eg survival and proliferation of multipotent hematopoietic cells, development of pDCs) through its interaction with a cell surface receptor that consists of two subunits. The α subunit (CD123) specifically binds IL-3, whereas the ??subunit is required for signaling and is common to the GMCSF-R and IL-5-R. Interplay of α and ??chains leads to the formation of a high-affinity receptor complex able to transduce proliferative, apoptotic and differentiative signals. Plasmacytoid DCs express IL3-R and differentiate into functional DCs with IL-3. The leukemic pDC counterpart also expresses high levels of IL3-Rα. Upon IL-3 treatment in vitro, leukemic cells become inducers of T-cell proliferation, as reported for normal pDCs.The role of IL3-R in oncogenesis has been explored in several animal models. Overexpression of the IL3-R ? chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Treilleux I et al., 2004, Clinical Cancer Research, 10: 7466-7474,