2'-5'-Oligoadenylate Synthetase-Like (OASL) (AA 1-100) protein (His tag)
Description
2'-5'-oligoadenylate synthase-like protein (OASL) contains 2 ubiquitin-like domains, and belongs to the 2-5A synthase family. The ubiquitin-like domains are essential for its antiviral activity. OASL can be induced by type I interferon (IFN) and viruses, and expressed in most tissues such as primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. OASL can specifically interacts with the ligand binding domain of the thyroid receptor (TR) without the presence of thyroid hormone. It does not have 2'-5'-OAS activity, but can bind double-stranded RNA. It also displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Synonyms: 2'-5'-oligoadenylate synthase-like protein,2'-5'-OAS-related protein,2'-5'-OAS-RP,59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid receptor-interacting protein 14,TR-interacting protein 14,TRIP-14,p59OASL,OASL,TRIP14