Recombinant Human Glutamate [NMDA] receptor subunit zeta-1 (GRIN1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 64.6kDa. Extracellular Domain: 19-559aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. Sensitivity to glutamate and channel kinetics depend on the subunit composition