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Description
BMP6 Antibody (clone morph-6.1, Biotin) LS-C96419. Specificity: Bone morphogenic protein 6. Pre-incubation of morph-6.1 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the antibody to tissue sections. Pre-incubation with other amino- terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as an irrelevant peptide does not inhibit specific tissue staining. Antigen distribution: Tissue sections: Positive staining can be observed in embryonic and adult central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in perinuclear region of most Schwann cells which form the myelin sheath. However, some Schwann cells were negative for morph-6.1. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by Desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative with morph-6.1. Specificity: Rat: Bone morphogenic Protein-6 (BMP-6) Synonyms are: vgr-1 (vegetal related) or DVR-6 (decapentaplegic vegetal related). Other species: phylogenetically highly conserved (human positive)
Immunogen
Aminoterminal synthetic peptide 1-29-KLh
Other Names
BMP6, BMP-6, Bone morphogenetic protein 6, VG-1-related protein, VGR1, VG-1-R, VGR, Vg1, Vg1-related sequence, VGR-1