Recombinant Human Integrin alpha-IIb (ITGA2B), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 29kDa. Partial: 639-887aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.